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名词简称

字数
1417 字
阅读时间
8 分钟
简称全称翻译
DN/DMNDefault Mode Network默认模式网络
SNsalience network突显网络
ICNsIntrinsic Connectivity Network固有连接网络
ICAIndependent Component Analysis独立成分分析
OGMovergeneral autobiographical memory过度概括的自传体记忆
rsFCresting-state functional connectivity静息态功能连接
FN/FPNfrontoparietal network额顶网络
CENcentral executive network中央执行网络
DANdorsal attention network背侧注意网络
ANaffective network情感网络
VANventral attention network腹侧注意网络
CTcortical thickness
SAsurface area
CVcortical volume
LGIlocal gyrification index局部褶皱化指数
GMVgray matter volume

Brain-based Sex Differences in Depression: A Systematic Review of Neuroimaging Studies https://doi.org/10.1007/s11682-023-00772-8

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研究研究设计研究组别样本量 (女/男)年龄 (岁) (平均±标准差)MRI/DTI/fMRI抑郁症测量工具药物治疗匹配变量
Amiri et al., 2021病例对照难治性抑郁症 (TRD) 健康对照组 (HC)21/10 18/1135.7±9.1 31.7±6.1fMRIHAMD-17未报告 (NR)未报告 (NR)
Ancelin et al., 2019病例对照终生MDD 无终生MDD320/290 (总)70.7 (中位数)MRIDSM-IV MINI抗抑郁药未报告 (NR)
Briceño et al., 2015病例对照MDD HC27/26 31/2646.1 (平均) 44.1 (平均)fMRIDSM-IV HDRS未报告 (NR)年龄,性别
Carceller-Sindreu et al., 2015病例对照首发MDD 缓解-复发MDD14/7 18/244.4±6.7 47.1±8.2MRIDSM-IV-TR HDRS精神药物年龄,性别分布,教育水平
慢性MDD HC16/4 24/1048.6±8.0 47.9±8.1
Chuang et al., 2017病例对照MDD HC82/24 24/10女: 15.72±1.10 男: 15.25±1.52 女: 15.89±1.42 男: 15.26±1.22fMRIDSM-IV抗抑郁药年龄,性别,用手习惯
Cyprien et al., 2014队列研究晚年抑郁症 (LLD) 非LLD75/45 137/21070.8±4.0 71.1±4.0MRIMINI CESD-抗抑郁药,抗高血压药药物服用
De Almeida et al., 2011病例对照MDD HC12/7 12/730.3±7 31.8±6.8fMRIHDRS抗抑郁药,情绪稳定剂,抗精神病药,抗焦虑药年龄,性别
Dong et al., 2022病例对照MDD HC76/48 137/106女: 25.68±7.90 男: 24.75±5.16 女: 21.33±4.28 男: 20.54±2.13fMRIDSM-IV-TR HAMD-17性别
Furtado et al., 2008病例对照TRD HC23/22 17/1337.53±11.3 36.6±11.09MRIDSM-IV MINI HDRS抗抑郁药 (TCA, NaSSA, NRI, RIMA, SNRI)年龄,性别
Geng et al., 2019病例对照躯体化抑郁症 (SD) 非躯体化抑郁症 (NSD) HC15/13 16/14 13/1737.21±7.16 34.10±9.91 35.83±8.15fMRIDSM-IV MINI HAMD-17抗抑郁药 (SSRI, SNRI, NaSSA, 苯二氮卓类)年龄,教育,性别
Hastings et al., 2004病例对照MDD HC10/8 10/838.9±11.4 34.8±13.6MRIDSM-III-R SCID-P SCID-NP性别
Ho et al., 2021病例对照MDD HC34/14 19/1616.32±1.19 15.75±1.22DTIDSM-IV K-SADS-PL RADS-2精神药物未报告 (NR)
Jenkins et al., 2018病例对照MDD HC32/16 25/15女: 21.72±1.28 男: 20.69±1.62 女: 21.00±1.63 男: 20.67±1.76fMRIDSM-IV-TR性别
Kliamovich et al., 2021队列研究MDD HC39/24 184/21514.88±1.44 14.87±1.78DTIDSM-IV SSAGA未报告 (NR)
Kong et al., 2013病例对照MDD HC16/13 17/16女: 28.88±9.71 男: 31.23±8.39 女: 28.00±9.09 男: 31.81±7.05MRIDSM-IV HAMD年龄,教育
Kronmuller et al., 2009病例对照首发MDD 缓解MDD未报告 (NR)未报告 (NR)MRIDSM-IV SCID HDRS年龄,性别
HC未报告 (NR)未报告 (NR)
Lavretsky et al., 1998病例对照早发MDD 晚发MDD10/10 10/1024.3±1.2 72.8±1.3MRIDSM-III-R未报告 (NR)
Lewine et al., 1995病例对照MDD 精神分裂症12/12 12/1230.6±11.4 28.3±9.4MRIDSM-III-R未报告 (NR)年龄,用手习惯
MacMaster et al., 2006病例对照MDD HC10/9 10/911.2±1.5 11.0±1.5MRIDSM-IV CDRS-R年龄,ICV
Mei et al., 2022病例对照MDD HC45/45 45/4533.3±11.5 34.0±12.4fMRIDSM-IV-TR HAMD-17年龄,教育,性别
Nielsen et al., 2020纵向队列MDD HC88/47 101/4513.9±0.6 13.9±0.6MRIDSM-IV CDI1名参与者服用年龄,母亲抑郁史
Piani et al., 2021病例对照MDD HC20/20 20/2024.1±3.1 24.5±2.2MRI, fMRIDSM-5 HAMD-17 DASS-21年龄,教育水平
Ritter et al., 2021病例对照MDD HC27/12 27/1233.5±11.3 32.5±11.2MRI (PWI)DSM-IV-TR SCID HAMD-17 BDI MADRS年龄,教育水平,性别
Soriano-Mas et al., 2011队列研究MDD HC30/17 30/1739.1±13.2 39.8±13.0MRIDSM-IV SCID HAMD-17抗抑郁药年龄,性别
Talishinsky et al., 2022病例对照TRD HC21/10 18/1135.7±9.1 31.7±6.1fMRIHAMD-17抗抑郁药年龄,性别,用手习惯
Ugwu et al., 2015病例对照MDD HC35/13 41/1431.0±11.0 28.5±11.0DTIDSM-IV-TR HAMD-17 MADRS BDI抗抑郁药年龄,教育
Yang et al., 2017病例对照MDD HC58/68 38/54MDD: 25.8±5.9 HC: 24.5±6.0MRIDSM-IV-TR HAMD-17年龄,性别,教育
Yao et al., 2014病例对照MDD HC45/45 45/4533.3±11.5 34.0±12.4fMRIDSM-IV-TR HAMD-17年龄,教育,性别
Young et al., 2017病例对照MDD HC42/42 42/4218.9±1.3 19.4±1.3fMRIDSM-IV-TR SCID年龄,教育,性别

抑郁症患病率性别差异

Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms https://doi.org/10.1037%2Fbul0000102

抑郁症临床性别差异

Sex differences in depression: Insights from clinical and preclinical studies https://doi.org/10.1016%2Fj.pneurobio.2019.01.006

sMRI 研究

华西医院:

Sex differences in the clinical characteristics and brain gray matter volume alterations in unmedicated patients with major depressive disorder https://doi.org/10.1038/s41598-017-02828-4

Sex-specific alterations of cortical morphometry in treatment-naïve patients with major depressive disorder https://doi.org/10.1038/s41386-021-01252-7

Sex differences of brain cortical structure in major depressive disorder https://doi.org/10.1093/psyrad/kkad014

Common and sex-specific differences in hypothalamic subunit volumes and their links with depressive symptoms in treatment-naïve patients with major depressive disorder https://doi.org/10.1007/s00429-025-02904-w

fMRI 研究

Large-Scale Network Dysfunction in Major Depressive Disorder-A Meta-analysis of Resting-State Functional Connectivity https://doi.org/10.1001/jamapsychiatry.2015.0071

Sex-specific resting state brain network dynamics in patients with major depressive disorder https://doi.org/10.1038/s41386-024-01799-1

Study of Sex Differences in Unmedicated Patients With Major Depressive Disorder by Using Resting State Brain Functional Magnetic Resonance Imaging https://doi.org/10.3389/fnins.2022.814410

Functional neuroimaging highlights sex as a critical variable in depression research https://doi.org/10.1038/s44220-025-00477-5

DTI 研究

White matter disturbances in major depressive disorder: a coordinated analysis across 20 international cohorts in the ENIGMA MDD working group https://doi.org/10.1038/s41380-019-0477-2

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